17alpha-Estradiol structure
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Common Name | 17alpha-Estradiol | ||
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CAS Number | 57-91-0 | Molecular Weight | 272.382 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 445.9±45.0 °C at 760 mmHg | |
Molecular Formula | C18H24O2 | Melting Point | 176-180ºC(lit.) | |
MSDS | Chinese USA | Flash Point | 209.6±23.3 °C | |
Symbol |
GHS08 |
Signal Word | Warning |
Use of 17alpha-EstradiolAlpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia. |
Name | 17α-estradiol |
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Synonym | More Synonyms |
Description | Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase[1]. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression[2]. |
In Vivo | Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17[3]. |
Cell Assay | Mouse embryonic fibroblast (MEF) cells are treated for the indicated time with Alpha-Estradiol (17 α-E2) or 17 β-E2 at 10 μM concentration. Inflammation is induced by LPS at a concentration of 10 ng/mL either alone or in combination with the respective estrogen[2]. |
Animal Admin | Newborn mice are randomLy assigned to six groups according to the kind of treatment: room air with vehicle injection (control, group 1), hyperoxia with vehicle injection (control, group 2), hyperoxia with 0.01 μg Alpha-Estradiol injection (group 3), hyperoxia with 0.1 μg Alpha-Estradiol injection (group 4), hyperoxia with 1.0 μg Alpha-Estradiol injection (group 5), and hyperoxia with 1.0 μg Alpha-Estradiol and 10.0 μg ICI182780 injection (antagonist of estrogen receptor α and β) (group 6). The pups receive daily subcutaneous injections of either Alpha-Estradiol in vehicle [dissolved in ethanol and diluted in 0.05 mL/mouse of phosphate-buffered saline (PBS)] or vehicle alone from postnatal days (PND) 7-16. On PND 7, the pups in the hyperoxia and Alpha-Estradiol-treatment groups are exposed to hyperoxia (75 ± 2 % O2) for 5 days (PND 7-12) and then returned to normoxia (room air) for 5 days, along with the nursing mothers, whereas pups in the normoxia group are kept in normoxia from PND 7-17. The pups are humanely euthanized on PND 9, 13 (14), and 17[3]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 445.9±45.0 °C at 760 mmHg |
Melting Point | 176-180ºC(lit.) |
Molecular Formula | C18H24O2 |
Molecular Weight | 272.382 |
Flash Point | 209.6±23.3 °C |
Exact Mass | 272.177643 |
PSA | 40.46000 |
LogP | 4.13 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.599 |
Storage condition | 0-6°C |
Water Solubility | ethanol: 50 mg/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS08 |
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Signal Word | Warning |
Hazard Statements | H351 |
Precautionary Statements | P281 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn: Harmful; |
Risk Phrases | R40;R48 |
Safety Phrases | 53-45-24/25-22 |
RIDADR | UN 2811 |
WGK Germany | 3 |
RTECS | KG3750000 |
Precursor 9 | |
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DownStream 1 | |
Virtual and biomolecular screening converge on a selective agonist for GPR30.
Nat. Chem. Biol. 2 , 207-12, (2006) Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor... |
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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J. Med. Chem. 52 , 7488-502, (2009) 17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3bet... |
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The effect of steroids on the in vitro migration of washed human spermatozoa in modified Tyrode's solution or in fasting human blood serum.
Fertil. Steril. 32(5) , 566-70, (1979) In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, alth... |
α-Estradiol |
a-Estradiol |
Oestra-1,3,5(10)-triene-3,17α-diol |
alfatradiol |
MFCD00064144 |
(17a)-Estra-1,3,5(10)-triene-3,17-diol |
3,17α-Dihydroxyestra-1,3,5(10)-triene |
Estra-1,3,5(10)-triene-3,17-diol, (17α)- |
trans-4-Hydroxycrotonic acid |
Epiestradiol |
Epiestrol |
Estra-1,3,5(10)-triene-3,17a-diol |
3,17-α-Dihydroxyoestra-1,3,5(10)-triene |
(17α)-Estra-1,3,5(10)-triene-3,17-diol |
3,17a-Dihydroxyestra-1,3,5(10)-triene |
Oestradiol-17a |
3,17a-Dihydroxyoestra-1,3,5(10)-triene |
Oestra-1,3,5(10)-triene-3,17a-diol |
17-Epiestradiol |
17α-Oestradiol |
3,17α-Dihydroxyoestra-1,3,5(10)-triene |
17a-Estradiol |
17α-Estradiol |
17α estradiol |
Oestradiol-17α |
(8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
Epiestradial |
Estradiol, 17α- |
EINECS 200-023-8 |
13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol |
17a-Oestradiol |
17alpha-Estradiol |
3,17-Dihydroxyestratriene |
Estradiol-17alpha |