3alpha,21-dihydroxy-5beta-pregnan-20-one

Modify Date: 2024-01-13 21:32:41

3alpha,21-dihydroxy-5beta-pregnan-20-one structure	Common Name	3alpha,21-dihydroxy-5beta-pregnan-20-one
	CAS Number	567-03-3	Molecular Weight	334.49300
	Density	1.115g/cm3	Boiling Point	470.3ºC at 760mmHg
	Molecular Formula	C₂₁H₃₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	252.3ºC

Use of 3alpha,21-dihydroxy-5beta-pregnan-20-one

Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].

Name	Tetrahydro 11-Deoxycorticosterone
Synonym	More Synonyms

Description	Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1]. In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].
In Vivo	Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species[2].
References	[1]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [2]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.

Density	1.115g/cm3
Boiling Point	470.3ºC at 760mmHg
Molecular Formula	C₂₁H₃₄O₃
Molecular Weight	334.49300
Flash Point	252.3ºC
Exact Mass	334.25100
PSA	57.53000
LogP	3.56760
Index of Refraction	1.54

Precursor 8
CAS#:1693-62-5 3α,21-diacetoxy... CAS#:2402-24-6 (3α,5β)-Tetrahy... CAS#:64-85-7 Desoxycorticosterone CAS#:1491-77-6 3α-Acetyloxy-5α...
CAS#:4057-84-5 ACETOXYLITHOCHO... CAS#:303-01-5 Pregnane-3,20-d... CAS#:56162-36-8 21-Hydroxy-20-o... CAS#:56162-37-9 (3α,5β)-3-Hydro...
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tetrahydrodeoxycorticosterone

DC Chemicals Limited
China
Product Name: Tetrahydrodeoxycorticosterone
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3alpha,21-dihydroxy-5beta-pregnan-20-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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