3alpha,21-dihydroxy-5beta-pregnan-20-one
Names
[ CAS No. ]:
567-03-3
[ Name ]:
3alpha,21-dihydroxy-5beta-pregnan-20-one
[Synonym ]:
tetrahydrodeoxycorticosterone
Biological Activity
[Description]:
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].
[Related Catalog]:
[In Vitro]
The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors[1]. In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not[1].
[In Vivo]
Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species[2].
[References]
Chemical & Physical Properties
[ Density]:
1.115g/cm3
[ Boiling Point ]:
470.3ºC at 760mmHg
[ Molecular Formula ]:
C21H34O3
[ Molecular Weight ]:
334.49300
[ Flash Point ]:
252.3ºC
[ Exact Mass ]:
334.25100
[ PSA ]:
57.53000
[ LogP ]:
3.56760
[ Index of Refraction ]:
1.54