3α,21-Dihydroxy-5α-pregnan-20-one-d3

Modify Date: 2024-01-14 14:39:25

3α,21-Dihydroxy-5α-pregnan-20-one-d3 Structure
3α,21-Dihydroxy-5α-pregnan-20-one-d3 structure
Common Name 3α,21-Dihydroxy-5α-pregnan-20-one-d3
CAS Number 203805-98-5 Molecular Weight 337.51
Density N/A Boiling Point N/A
Molecular Formula C21H31D3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3α,21-Dihydroxy-5α-pregnan-20-one-d3


3α,21-Dihydroxy-5α-pregnan-20-one-d3 (THDOC-d3) is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

 Names

Name 3α,21-Dihydroxy-5α-pregnan-20-one-d3

 3α,21-Dihydroxy-5α-pregnan-20-one-d3 Biological Activity

Description 3α,21-Dihydroxy-5α-pregnan-20-one-d3 (THDOC-d3) is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

 Chemical & Physical Properties

Molecular Formula C21H31D3O3
Molecular Weight 337.51