1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione

Modify Date: 2024-01-14 21:20:57

1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione Structure
1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione structure
Common Name 1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione
CAS Number 56527-42-5 Molecular Weight 278.26
Density 1.78g/cm3 Boiling Point N/A
Molecular Formula C9H11FN2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione


5-Fluoro-4’-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoropyrimidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 5-Fluoro-4’-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.78g/cm3
Molecular Formula C9H11FN2O5S
Molecular Weight 278.26
Exact Mass 278.03700
PSA 140.85000

 Synonyms

Uridine,5-fluoro-4'-thio
5-fluoro-4-thio-uridine
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