1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione

Names

[ Name ]:
1-[3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-fluoro-pyrimidine-2,4-dione

[Synonym ]:
Uridine,5-fluoro-4'-thio
5-fluoro-4-thio-uridine

Biological Activity

[Description]:

5-Fluoro-4’-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.78g/cm3

[ Molecular Formula ]:
C₉H₁₁FN₂O₅S

[ Molecular Weight ]:
278.26

[ Exact Mass ]:
278.03700

[ PSA ]:
140.85000

Related Compounds

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