L-serine

Modify Date: 2024-01-01 19:32:04

L-serine Structure
L-serine structure
 Common Name L-serine
CAS Number 56-45-1 Molecular Weight 105.093
Density 1.6 Boiling Point 394.8±32.0 °C at 760 mmHg
Molecular Formula C3H7NO3 Melting Point 222ºC
MSDS Chinese USA Flash Point 192.6±25.1 °C

 Use of L-serine


L-Serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

 Names

Name L-serine
Synonym More Synonyms

 L-serine Biological Activity

Description L-Serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. In cell cultures, L-Serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization.L-Serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system[1].
References

[1]. de Koning TJ, et al. L-Serine in disease and development. Biochem J. 2003 May 1;371(Pt 3):653-61.

 Chemical & Physical Properties

Density 1.6
Boiling Point 394.8±32.0 °C at 760 mmHg
Melting Point 222ºC
Molecular Formula C3H7NO3
Molecular Weight 105.093
Flash Point 192.6±25.1 °C
Exact Mass 105.042595
PSA 83.55000
LogP -1.58
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.519
Storage condition 2~8℃
Water Solubility 250 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VT8100000
CHEMICAL NAME :
Serine, L-
CAS REGISTRY NUMBER :
56-45-1
BEILSTEIN REFERENCE NO. :
1721404
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C3-H7-N-O3
MOLECULAR WEIGHT :
105.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81867 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81867 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 5855 (estimated) No. of Female Employees: 4144 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VT8100000
HS Code 29225000

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles266

More Articles
Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....
8DSS-promoted remineralization of initial enamel caries in vitro.

J. Dent. Res. 93(5) , 520-4, (2014)

Peptides containing 8 repeats of aspartate-serine-serine (8DSS) have been shown to promote the nucleation of calcium phosphate from solution into human enamel. Here we tested the ability of 8DSS to pr...
Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...

 Synonyms

L-Serin
(2R)-2-amino-3-hydroxypropanoic acid
Ser
S-serine
(S)-2-Amino-3-hydroxypropionic acid
SERINE,USP
Serine
SERINE,L
(2R)-2-Amino-3-hydroxypropionic acid
H-D-Ser-OH
L-3-Hydroxy-2-aminopropionic acid
(S)-a-Amino-b-hydroxypropionic acid
(S)-2-amino-3-hydroxypropanoic acid
Propanoic acid, 2-amino-3-hydroxy-, (S)-
H-Ser-OH
H-L-SER-OH
(S)-2-amino-3-hydroxy-Propanoic acid
2-Amino-3-hydroxypropanoic acid, (S)-
(R)-(-)-Serine
d-ser
Serine, D-
D-Serine
Serine, L-
(S)-(-)-serine
.α.-Amino-.β.-hydroxypropionic acid
L-2-Amino-3-hydroxypropionic acid
(-)-Serine
L-Serine
(R)-Serine
3-hydroxy-L-Alanine
L-Ser
EINECS 200-274-3
MFCD00064224
b-Hydroxy-L-alanine
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Related Compounds: More...
L-Serine
632-13-3
L-Serine-N
59935-32-9
L-Serine-C
201595-68-8
L-Serine-d3
105591-10-4
L-Serine-d2
95034-57-4
L-Serine-d7
935275-35-7
L-Serine-2-C
89232-76-8
L-Serine-13C
89232-77-9
L-Serine-1-13C
81201-84-5
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