DB04760

Modify Date: 2024-01-11 09:01:27

DB04760 structure	Common Name	DB04760
	CAS Number	544678-85-5	Molecular Weight	410.41700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₀F₂N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DB04760

DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].

Name	pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)
Synonym	More Synonyms

Description	DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease
Target	MMP-13:8 nM (IC50)
References	[1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9. [2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198.

Molecular Formula	C₂₂H₂₀F₂N₄O₂
Molecular Weight	410.41700
Exact Mass	410.15500
PSA	83.98000
LogP	4.01340

MMP-13 INHIBITOR

N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide

DC Chemicals Limited
China
Product Name: DB04760
Price: $500.0/100mg $1000.0/250mg $2000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MMP-13 Inhibitor
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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