DB04760

Names

[ Name ]:
DB04760

[Synonym ]:
MMP-13 INHIBITOR
N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide

Biological Activity

[Description]:

DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Research Areas >> Neurological Disease

[Target]

MMP-13:8 nM (IC50)

[References]

[1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9.

[2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀F₂N₄O₂

[ Molecular Weight ]:
410.41700

[ Exact Mass ]:
410.15500

[ PSA ]:
83.98000

[ LogP ]:
4.01340

Related Compounds

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