544678-85-5

544678-85-5 structure

Name: DB04760
Chemical Name: pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)
CAS Number: 544678-85-5
Molecular Formula: C₂₂H₂₀F₂N₄O₂
Molecular Weight: 410.41700
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2018-12-18 12:01:24
Modify Date: 2025-09-23 00:23:32
DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].

Name	pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)
Synonyms	MMP-13 INHIBITOR N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide

Description	DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Neurological Disease
Target	MMP-13:8 nM (IC50)
References	[1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9. [2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198.