Fluorescein sodium

Modify Date: 2024-01-03 05:52:42

Fluorescein sodium structure	Common Name	Fluorescein sodium
	CAS Number	518-47-8	Molecular Weight	376.270
	Density	1.601 g/cm3 (20ºC)	Boiling Point	620.8ºC at 760 mmHg
	Molecular Formula	C₂₀H₁₀Na₂O₅	Melting Point	320 °C
	MSDS	USA	Flash Point	232.6ºC

Use of Fluorescein sodium

Fluorescein (Uranine) sodium is widely used as a fluorescent tracer in medicinal and biological applications and tumor infected tissues tracer. Fluorescein (Uranine) sodium is a representative green fluorophore that has been widely used as a scaffold of practically useful green fluorescent probes[1][2].

Name	Uranine
Synonym	More Synonyms

Description	Fluorescein (Uranine) sodium is widely used as a fluorescent tracer in medicinal and biological applications and tumor infected tissues tracer. Fluorescein (Uranine) sodium is a representative green fluorophore that has been widely used as a scaffold of practically useful green fluorescent probes[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Fluorescein is a synthetic organic photoactive dye compound soluble in water, alcohol and polar solvents[1].
References	[1]. Hirabayashi K, et al. Analysis of chemical equilibrium of silicon-substituted fluorescein and its application to develop a scaffold for red fluorescent probes. Anal Chem. 2015;87(17):9061-9069. [2]. Negm NA, et al. Fluorescein dye derivatives and their nanohybrids: Synthesis, characterization and antimicrobial activity. J Photochem Photobiol B. 2016;162:421-433.

Density	1.601 g/cm3 (20ºC)
Boiling Point	620.8ºC at 760 mmHg
Melting Point	320 °C
Molecular Formula	C₂₀H₁₀Na₂O₅
Molecular Weight	376.270
Flash Point	232.6ºC
Exact Mass	376.032349
PSA	81.65000
LogP	4.54220
Water Solubility	500 g/L (20 ºC)

Fluorescein sodium MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LM5425000

CHEMICAL NAME :: Fluorescein, disodium salt

CAS REGISTRY NUMBER :: 518-47-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C20-H10-O5.2Na

MOLECULAR WEIGHT :: 376.28

WISWESSER LINE NOTATION :: T C666 BO EVJ IR BVQ& MQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14 mg/kg/10M-I

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 7142 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - hemorrhage Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6721 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4738 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg/28D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4 gm/kg/28D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 gm/kg/79W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 933 mg/kg

SEX/DURATION :: female 5-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50100 ug/L

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1436 No. of Facilities: 2278 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 14785 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1436 No. of Facilities: 5145 (estimated) No. of Industries: 76 No. of Occupations: 69 No. of Employees: 94491 (estimated) No. of Female Employees: 21830 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36
Safety Phrases	S22-S24/25-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	LM5425000
HS Code	3204200000

3′,6′-dibromofluoran

CAS#:87021-26-9

Fluorescein sodium

CAS#:518-47-8

Literature: Xu, Qingling; Lee, Kyung-Ah; Lee, Songyi; Lee, Kyung Mi; Lee, Won-Jae; Yoon, Juyoung Journal of the American Chemical Society, 2013 , vol. 135, # 26 p. 9944 - 9949

3',6'-dibromo-3...

CAS#:1443665-54-0

Fluorescein sodium

CAS#:518-47-8

Literature: Xu, Qingling; Lee, Kyung-Ah; Lee, Songyi; Lee, Kyung Mi; Lee, Won-Jae; Yoon, Juyoung Journal of the American Chemical Society, 2013 , vol. 135, # 26 p. 9944 - 9949

Precursor 2
CAS#:87021-26-9 3′,6′-dibromofluoran CAS#:1443665-54-0 3',6'-dibromo-3...
DownStream 3
CAS#:131205-61-3 butyl 2-(3-buto... CAS#:335193-91-4 N-Butylfluorescein CAS#:15086-94-9 Eosin Y

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods.

Food Chem. 194 , 749-57, (2015)

Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natura...

Transparent intracortical microprobe array for simultaneous spatiotemporal optical stimulation and multichannel electrical recording.

Nature Methods 12 , 1157-62, (2015)

Optogenetics, the selective excitation or inhibition of neural circuits by light, has become a transformative approach for dissecting functional brain microcircuits, particularly in in vivo rodent mod...

Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells.

J. Virol. 89 , 9896-908, (2015)

Coronaviruses (CoVs) have shown neuroinvasive properties in humans and animals secondary to replication in peripheral organs, but the mechanism of neuroinvasion is unknown. The major aim of our work w...

URANIN

URANINE

c.i.766

D and C yellow dye No 8

EINECS 208-253-0

Fluorescein,disodium salt

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, sodium salt (1:2)

spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, disodium salt

uranineo

Yellow No. 8,NaFl,NaFluo

Acid Yellow 73,D&C

MFCD00167039

ful-glo

fluoresceine disodium salt

Fluorescein Sodium Salt

furanium

Fluorin

9-(2-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one disodium salt

YELLOW 8

Sodium 3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)

Disodium 3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

Fluorescein Disodium Salt

Fluorone

Acid yellow 73

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fluorescein sodium
Price: ￥98.0/100g ￥298.0/500g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Fluorescein Sodium
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fluorescein disodium salt
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Fluorescein Sodium Salt
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Uranine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Fluorescein sodium suppliers

Fluorescein sodium price

Fluorescein sodium

Use of Fluorescein sodium

Names