Fluorescein sodium
Names
[ CAS No. ]:
518-47-8
[ Name ]:
Fluorescein sodium
[Synonym ]:
URANIN
URANINE
c.i.766
D and C yellow dye No 8
EINECS 208-253-0
Fluorescein,disodium salt
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, sodium salt (1:2)
spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-, disodium salt
uranineo
Yellow No. 8,NaFl,NaFluo
Acid Yellow 73,D&C
MFCD00167039
ful-glo
fluoresceine disodium salt
Fluorescein Sodium Salt
furanium
Fluorin
9-(2-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one disodium salt
YELLOW 8
Sodium 3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)
Disodium 3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
Fluorescein Disodium Salt
Fluorone
Acid yellow 73
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.601 g/cm3 (20ºC)
[ Boiling Point ]:
620.8ºC at 760 mmHg
[ Melting Point ]:
320 °C
[ Molecular Formula ]:
C20H10Na2O5
[ Molecular Weight ]:
376.270
[ Flash Point ]:
232.6ºC
[ Exact Mass ]:
376.032349
[ PSA ]:
81.65000
[ LogP ]:
4.54220
[ Water Solubility ]:
500 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LM5425000
- CHEMICAL NAME :
- Fluorescein, disodium salt
- CAS REGISTRY NUMBER :
- 518-47-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C20-H10-O5.2Na
- MOLECULAR WEIGHT :
- 376.28
- WISWESSER LINE NOTATION :
- T C666 BO EVJ IR BVQ& MQ &-NA- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 14 mg/kg/10M-I
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 7142 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - hemorrhage Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6721 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Blood - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4738 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg/28D-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4 gm/kg/28D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19 gm/kg/79W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 gm/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 933 mg/kg
- SEX/DURATION :
- female 5-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - postpartum Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 50100 ug/L
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1436 No. of Facilities: 2278 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 14785 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1436 No. of Facilities: 5145 (estimated) No. of Industries: 76 No. of Occupations: 69 No. of Employees: 94491 (estimated) No. of Female Employees: 21830 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36
[ Safety Phrases ]:
S22-S24/25-S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
LM5425000
[ HS Code ]:
3204200000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Food Chem. 194 , 749-57, (2015)
Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natura...
Transparent intracortical microprobe array for simultaneous spatiotemporal optical stimulation and multichannel electrical recording.Nature Methods 12 , 1157-62, (2015)
Optogenetics, the selective excitation or inhibition of neural circuits by light, has become a transformative approach for dissecting functional brain microcircuits, particularly in in vivo rodent mod...
Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells.J. Virol. 89 , 9896-908, (2015)
Coronaviruses (CoVs) have shown neuroinvasive properties in humans and animals secondary to replication in peripheral organs, but the mechanism of neuroinvasion is unknown. The major aim of our work w...