Fluorescein-thiourea-PEG2-azide

Modify Date: 2024-01-10 11:42:28

Fluorescein-thiourea-PEG2-azide Structure
Fluorescein-thiourea-PEG2-azide structure
Common Name Fluorescein-thiourea-PEG2-azide
CAS Number 1146195-72-3 Molecular Weight 563.582
Density N/A Boiling Point N/A
Molecular Formula C27H25N5O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fluorescein-thiourea-PEG2-azide


Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Fluorescein-PEG2-Azide
Synonym More Synonyms

 Fluorescein-thiourea-PEG2-azide Biological Activity

Description Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C27H25N5O7S
Molecular Weight 563.582
Exact Mass 563.147461
LogP 2.35

 Synonyms

MFCD23726635
Benzoic acid, 5-[[[[2-[2-(2-azidoethoxy)ethoxy]ethyl]amino]thioxomethyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
5-[({2-[2-(2-Azidoethoxy)ethoxy]ethyl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
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