Pomalidomide-PEG2-azide

Modify Date: 2024-04-03 01:09:57

Pomalidomide-PEG2-azide Structure
Pomalidomide-PEG2-azide structure
Common Name Pomalidomide-PEG2-azide
CAS Number 2267306-14-7 Molecular Weight 444.40
Density N/A Boiling Point N/A
Molecular Formula C19H20N6O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide-PEG2-azide


Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

 Names

Name Pomalidomide-PEG2-azide

 Pomalidomide-PEG2-azide Biological Activity

Description Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

 Chemical & Physical Properties

Molecular Formula C19H20N6O7
Molecular Weight 444.40
Storage condition -20°C