Fluorescein-thiourea-PEG2-azide

Names

[ Name ]:
Fluorescein-thiourea-PEG2-azide

[Synonym ]:
MFCD23726635
Benzoic acid, 5-[[[[2-[2-(2-azidoethoxy)ethoxy]ethyl]amino]thioxomethyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
5-[({2-[2-(2-Azidoethoxy)ethoxy]ethyl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

Biological Activity

[Description]:

Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₅N₅O₇S

[ Molecular Weight ]:
563.582

[ Exact Mass ]:
563.147461

[ LogP ]:
2.35

Related Compounds

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