Alloepipregnanolone

Modify Date: 2024-01-02 16:34:23

Alloepipregnanolone structure	Common Name	Alloepipregnanolone
	CAS Number	516-55-2	Molecular Weight	318.49300
	Density	1.053g/cm3	Boiling Point	431.2ºC at 760mmHg
	Molecular Formula	C₂₁H₃₄O₂	Melting Point	200℃
	MSDS	N/A	Flash Point	183.9ºC

Use of Alloepipregnanolone

Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.

Name	3β-hydroxy-5α-pregnan-20-one
Synonym	More Synonyms

Description	Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vivo	On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol[1].
Animal Admin	Mice[1] Male Swiss mice are pretreated with Alloepipregnanolone (isopregnanolone: 0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals tested using the plus-maze apparatus. The first experiment defines the doses of ethanol that does or does not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with Alloepipregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) is studied[1].
References	[1]. Debatin T, et al. Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol. Rev Bras Psiquiatr. 2006 Mar;28(1):18-23.

Density	1.053g/cm3
Boiling Point	431.2ºC at 760mmHg
Melting Point	200℃
Molecular Formula	C₂₁H₃₄O₂
Molecular Weight	318.49300
Flash Point	183.9ºC
Exact Mass	318.25600
PSA	37.30000
LogP	4.59520
Index of Refraction	1.524

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4383200

CHEMICAL NAME :: 5-alpha-Pregnan-20-one, 3-beta-hydroxy-

CAS REGISTRY NUMBER :: 516-55-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H34-O2

MOLECULAR WEIGHT :: 318.55

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 FV1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

RTECS	TU4383200

Precursor 10
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DownStream 6
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ALLOPREGNAN-3B-OL-20-ONE

3beta-hydroxy-5alpha-pregnan-20-one

3-Hydroxypregnan-20-one

Alloepipregnanolone

5A-PREGNAN-3B-OL-20-ONE

Tetrahydroprogesterone

ALLOPREGNANOLONE

ISOPREGNANOLONE

EINECS 208-224-2

MFCD00064935

Pregnan-20-one,3-hydroxy-, (3b,5a)-

epi-allopregnanolone

DC Chemicals Limited
China
Product Name: Alloepipregnanolone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pregnan-20-one,3-hydroxy-, (3b,5a)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Alloepipregnanolone
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: ￥600/100 mg

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