7,4'-Di-O-methylapigenin

Modify Date: 2024-01-04 22:08:53

7,4'-Di-O-methylapigenin Structure
7,4'-Di-O-methylapigenin structure
Common Name 7,4'-Di-O-methylapigenin
CAS Number 5128-44-9 Molecular Weight 298.290
Density 1.3±0.1 g/cm3 Boiling Point 515.2±50.0 °C at 760 mmHg
Molecular Formula C17H14O5 Melting Point N/A
MSDS N/A Flash Point 193.3±23.6 °C

 Use of 7,4'-Di-O-methylapigenin


The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]

 Names

Name apigenin 7,4'-dimethyl ether
Synonym More Synonyms

 7,4'-Di-O-methylapigenin Biological Activity

Description The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Related Catalog
References

[1]. Alvarez, M.E. et al.Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.Farmaco. Jun-Jul;55(6-7):502-5.doi:10.1016/S0014-827X(00)00067-7(2000).

[2]. Mangoyi, R., Midiwo, J. & Mukanganyama, S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC complementary and alternative medicine 15, 405, doi:10.1186/s12906-015-0934-7 (2015).

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 515.2±50.0 °C at 760 mmHg
Molecular Formula C17H14O5
Molecular Weight 298.290
Flash Point 193.3±23.6 °C
Exact Mass 298.084137
PSA 68.90000
LogP 3.40
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.622
Storage condition -20℃

 Safety Information

HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

Genkwanin 4'-methyl ether
Flavone, 5-hydroxy-4',7-dimethoxy-
4',7-Dimethylapigenin
Apigenin dimethyl ether
7,4'-dimethylapigenin
5-Hydroxy-4',7-dimethoxyflavone
5-Hydroxy-4',7-dimethoxy-flavone
5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
7,4'-di-O-methylapigenin
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
Apigenin 7,4'-dimethyl ether
4H-1-Benzopyran-4-one, 5-hydroxy-7-methoxy-2- (4-methoxyphenyl)-
Apigenin 4',7-dimethyl ether
4H-1-Benzopyran-4-one, 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-
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