7,4'-Di-O-methylapigenin
7,4'-Di-O-methylapigenin structure
|
Common Name | 7,4'-Di-O-methylapigenin | ||
|---|---|---|---|---|
| CAS Number | 5128-44-9 | Molecular Weight | 298.290 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 515.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H14O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 193.3±23.6 °C | |
Use of 7,4'-Di-O-methylapigeninThe compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | apigenin 7,4'-dimethyl ether |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 515.2±50.0 °C at 760 mmHg |
| Molecular Formula | C17H14O5 |
| Molecular Weight | 298.290 |
| Flash Point | 193.3±23.6 °C |
| Exact Mass | 298.084137 |
| PSA | 68.90000 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.622 |
| InChIKey | LZERJKGWTQYMBB-UHFFFAOYSA-N |
| SMILES | COc1ccc(-c2cc(=O)c3c(O)cc(OC)cc3o2)cc1 |
| Storage condition | -20℃ |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2914509090 |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 9 | |
CAS#:480-41-1
CAS#:74-88-4
CAS#:5631-70-9
CAS#:480-44-4
CAS#:186581-53-3
CAS#:520-36-5
CAS#:77-78-1
CAS#:29424-96-2
CAS#:771481-08-4
CAS#:771480-96-7
CAS#:100-09-4
CAS#:19103-54-9
CAS#:520-18-3
CAS#:529-53-3
CAS#:6601-66-7
CAS#:49620-13-5
CAS#:5689-38-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Genkwanin 4'-methyl ether |
| 4',7-Dimethylapigenin |
| Apigenin dimethyl ether |
| 7,4'-dimethylapigenin |
| 5-Hydroxy-4',7-dimethoxyflavone |
| 5-Hydroxy-4',7-dimethoxy-flavone |
| 5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
| 7,4'-di-O-methylapigenin |
| 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one |
| Apigenin 7,4'-dimethyl ether |
| Apigenin 4',7-dimethyl ether |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of apigenin 7,4'-dimethyl ether? |
| A: Boiling point of apigenin 7,4'-dimethyl ether is 515.2±50.0 °C at 760 mmHg. |
| Q: What are the storage conditions for apigenin 7,4'-dimethyl ether? |
| A: Storage conditions for apigenin 7,4'-dimethyl ether: -20℃. |
| Q: What is the English name of apigenin 7,4'-dimethyl ether? |
| A: The English name of apigenin 7,4'-dimethyl ether is apigenin 7,4'-dimethyl ether. |
| Q: What is the polar surface area (PSA) of apigenin 7,4'-dimethyl ether? |
| A: Polar surface area (PSA) of apigenin 7,4'-dimethyl ether is 68.90000. |
| Q: What is the CAS number of apigenin 7,4'-dimethyl ether? |
| A: CAS number of apigenin 7,4'-dimethyl ether is 5128-44-9. |
| Q: What is the molecular weight of apigenin 7,4'-dimethyl ether? |
| A: Molecular weight of apigenin 7,4'-dimethyl ether is 298.290. |
| Q: What is the SMILES notation of apigenin 7,4'-dimethyl ether? |
| A: SMILES notation of apigenin 7,4'-dimethyl ether is COc1ccc(-c2cc(=O)c3c(O)cc(OC)cc3o2)cc1. |
| Q: What is the molecular formula of apigenin 7,4'-dimethyl ether? |
| A: Molecular formula of apigenin 7,4'-dimethyl ether is C17H14O5. |
| Q: What are the downstream products of apigenin 7,4'-dimethyl ether? |
| A: Related downstream products(CAS) of apigenin 7,4'-dimethyl ether: 100-09-4;19103-54-9;520-18-3;529-53-3;520-36-5;6601-66-7;49620-13-5;5631-70-9;5689-38-3. |
| Q: What is the InChIKey of apigenin 7,4'-dimethyl ether? |
| A: InChIKey of apigenin 7,4'-dimethyl ether is LZERJKGWTQYMBB-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |