FAPy-adenine
Modify Date: 2024-01-11 18:42:40
FAPy-adenine structure
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Common Name | FAPy-adenine | ||
|---|---|---|---|---|
| CAS Number | 5122-36-1 | Molecular Weight | 281.266 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 464.7±47.0 °C at 760 mmHg | |
| Molecular Formula | C5H7N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 234.8±29.3 °C | |
Use of FAPy-adenineFAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3]. |
| Name | 4,6-diamino-5-formamidopyrimidine |
|---|---|
| Synonym | More Synonyms |
| Description | FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1]. |
| In Vivo | The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1]. |
| References |
[1]. Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.7±47.0 °C at 760 mmHg |
| Molecular Formula | C5H7N5O |
| Molecular Weight | 281.266 |
| Flash Point | 234.8±29.3 °C |
| Exact Mass | 281.080048 |
| PSA | 106.92000 |
| LogP | 1.92 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.674 |
| HS Code | 2933599090 |
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FAPy-adenine CAS#:5122-36-1 |
| Literature: Abrams; Clark Journal of the American Chemical Society, 1951 , vol. 73, p. 4609 Full Text View citing articles Show Details Cavalieri; Brown Journal of the American Chemical Society, 1949 , vol. 71, p. 2246 |
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FAPy-adenine CAS#:5122-36-1 |
| Literature: Cavalieri; Tinker; Bendich Journal of the American Chemical Society, 1949 , vol. 71, p. 535 |
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FAPy-adenine CAS#:5122-36-1 |
| Literature: Vieira; Steenken Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6986 - 6994 |
CAS#:73-24-5| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Fapyade |
| FAPy |
| 3H-Pyrazol-3-one, 2,4-dihydro-2-(4-nitrophenyl)-5-phenyl- |
| N-(4,6-diaminopyrimidin-5-yl)formamide |
| 4,6-Diamino-5-formamidopyrimidine |
| 4,6-Diamino-5-N-formamidopyrimidine |
| 2-(4-Nitrophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one |
| 4,6-Diamino-5-pyrimidinylformamide |