Journal of the American Chemical Society

Pattern of hydroxy radical reaction with adenine and its nucleosides and nucleotides. Characterization of two types of isomeric hydroxy adduct and their unimolecular …

A Vieira, S Steenken

Index: Vieira; Steenken Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6986 - 6994

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Citation Number: 120

Abstract

Abstract: The'OH radical reacts in aqueous solution with adenine, 9-methyladenine, adenosine and its 3'-and 5'-mono-and 3', 5'-diphosphates, and with the corresponding 2'- deoxyadenosines by addition to C4 and to C8 of the purine system. The resulting hydroxycyclohexa-or penta (aza) dienyl-type radicals A40H'(formed by'OH addition at C4) and A80H'(by addition at C8) undergo a dehydration and a ring-opening reaction, ...