12-Hydroxyabieta-8(14),9(11),12-trien-7-one
Modify Date: 2024-01-12 15:54:52
12-Hydroxyabieta-8(14),9(11),12-trien-7-one structure
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Common Name | 12-Hydroxyabieta-8(14),9(11),12-trien-7-one | ||
|---|---|---|---|---|
| CAS Number | 511-05-7 | Molecular Weight | 300.435 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 437.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H28O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 186.4±21.3 °C | |
Use of 12-Hydroxyabieta-8(14),9(11),12-trien-7-oneSugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
| Name | sugiol |
|---|---|
| Synonym | More Synonyms |
| Description | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β |
| In Vitro | Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.2±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.435 |
| Flash Point | 186.4±21.3 °C |
| Exact Mass | 300.208923 |
| PSA | 37.30000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.539 |
| Hazard Codes | Xi |
|---|
| 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS,10aS)- |
| 12-Hydroxyabieta-8,11,13-triene-7-one |
| 7-oxo-8,11,13-abietatrien-12-ol |
| 12-Hydroxy-abieta-8,11,13-trien-7-on |
| 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS-trans)- |
| Podocarpa-8,11,13-trien-7-one, 12-hydroxy-13-isopropyl- |
| 12-hydroxy-abieta-8,11,13-trien-7-one |
| 12-Hydroxyabieta-8(14),9(11),12-trien-7-one |
| 10-Deoxoxanthoperol |
| 12-hidroxyabieta-8,11,13-trien-7-one |
- BioBioPha
- China
- Product Name: 12-Hydroxyabieta-8(14),9(11),12-trien-7-one
- Price: ￥3400.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 12-Hydroxyabieta-8(14),9(11),12-trien-7-one
- Price: ￥4640.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Sugiol
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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