511-05-7

511-05-7 structure

Name: 12-Hydroxyabieta-8(14),9(11),12-trien-7-one
Chemical Name: sugiol
CAS Number: 511-05-7
Molecular Formula: C₂₀H₂₈O₂
Molecular Weight: 300.435
Catalog: Natural product Moss
Create Date: 2018-09-29 12:13:31
Modify Date: 2024-01-12 15:54:52
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

Name	sugiol
Synonyms	9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS,10aS)- 12-Hydroxyabieta-8,11,13-triene-7-one 7-oxo-8,11,13-abietatrien-12-ol 12-Hydroxy-abieta-8,11,13-trien-7-on 9(1H)-Phenanthrenone, 2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-, (4aS-trans)- Podocarpa-8,11,13-trien-7-one, 12-hydroxy-13-isopropyl- 12-hydroxy-abieta-8,11,13-trien-7-one 12-Hydroxyabieta-8(14),9(11),12-trien-7-one 10-Deoxoxanthoperol 12-hidroxyabieta-8,11,13-trien-7-one

Description	Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β
In Vitro	Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
References	[1]. Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71(4):300-5.

Hazard Codes	Xi