N-Acetyl Mesalazine
N-Acetyl Mesalazine structure
|
Common Name | N-Acetyl Mesalazine | ||
|---|---|---|---|---|
| CAS Number | 51-59-2 | Molecular Weight | 195.17 | |
| Density | 1.462 g/cm3 | Boiling Point | 480.2ºC at 760 mmHg | |
| Molecular Formula | C9H9NO4 | Melting Point | 228-230ºC | |
| MSDS | Chinese USA | Flash Point | 244.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of N-Acetyl MesalazineN-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis[1]. |
| Name | 5-acetamido-2-hydroxybenzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.462 g/cm3 |
|---|---|
| Boiling Point | 480.2ºC at 760 mmHg |
| Melting Point | 228-230ºC |
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 |
| Flash Point | 244.2ºC |
| Exact Mass | 195.05300 |
| PSA | 86.63000 |
| LogP | 1.12180 |
| Index of Refraction | 1.661 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924299090 |
|
~66%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: DAK-Laboratoriet Patent: US4933330 A1, 1990 ; |
|
~91%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Khan, Md. Umar; Baseer; Kumar, S. Ranjith; Saravanakumar; Prasannanjali; Gupta, P. Badarinadh; Kaushik, Vipin K.; Handa, Vijay K.; Islam, Aminul Synthetic Communications, 2010 , vol. 40, # 15 p. 2241 - 2253 |
|
~%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Brown, Joseph P.; McGarraugh, Geoff V.; Parkinson, Thomas M.; Wingard, Robert E.; Onderdonk, Andrew B. Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1300 - 1307 |
|
~82%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Peng, Yanqing; Song, Gonghua; Ding, Fang Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 9 p. 2021 - 2023 |
|
~%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Huebner Justus Liebigs Annalen der Chemie, 1879 , vol. 195, p. 37 |
|
~%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Huebner Justus Liebigs Annalen der Chemie, 1879 , vol. 195, p. 37 |
|
~%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Grandmougin Chemische Berichte, 1906 , vol. 39, p. 3930 |
|
~%
N-Acetyl Mesalazine CAS#:51-59-2 |
| Literature: Huebner Justus Liebigs Annalen der Chemie, 1879 , vol. 195, p. 37 |
| Precursor 8 | |
|---|---|
| DownStream 4 | |
![N-(7,9-dioxo-10-oxa-8-azabicyclo[4.4.0]deca-2,4,11-trien-4-yl)acetamide structure](https://www.chemsrc.com/caspic/404/1925-98-0.png)
CAS#:1925-98-0
CAS#:30653-83-9
CAS#:118828-85-6
CAS#:400039-29-4| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|
Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection.
J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995) A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in h... |
|
|
Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study.
J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009) : A multicenter, double-blind study was conducted to evaluate the safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate ulcerative colitis (UC).: Sixty-eigh... |
|
|
Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid.
J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994) 5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic... |
| CJ 46A |
| N-Acetyl Mesalazine |
| 5-Acetamidosalicylic acid |
| N-Acetyl-5-aminosalicylic acid |
| 3-Carboxyparacetamol |
| 5-acetylamino salicylic acid |
| Acetylmesalazine 5-Acetamidosalicylic acid N-Acetyl-5-aminosalicylic acid |
| 5-acetamido-2-hydroxy-benzoic acid |