GGTI 2417
Modify Date: 2025-08-28 11:57:31
GGTI 2417 structure
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Common Name | GGTI 2417 | ||
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| CAS Number | 501010-05-5 | Molecular Weight | 455.550 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 755.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H33N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 410.6±32.9 °C | |
Use of GGTI 2417GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I; exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM; increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27. |
| Name | Methyl N-({(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-1-piperazinyl}carbonyl)-L-leucinate |
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| Synonym | More Synonyms |
| Description | GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I; exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM; increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27. |
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| References | References 1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558. 2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. 3. Falsetti SC, et al. Mol Cell Biol. 2007 Nov;27(22):8003-14. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 755.3±60.0 °C at 760 mmHg |
| Molecular Formula | C24H33N5O4 |
| Molecular Weight | 455.550 |
| Flash Point | 410.6±32.9 °C |
| Exact Mass | 455.253265 |
| LogP | 2.61 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.578 |
| L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester |
| MFCD25976817 |
| Methyl N-({(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-1-piperazinyl}carbonyl)-L-leucinate |