GGTI-286 dihydrochloride
Modify Date: 2024-04-02 14:47:28
GGTI-286 dihydrochloride structure
|
Common Name | GGTI-286 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 181141-66-2 | Molecular Weight | 466.037 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H32ClN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GGTI-286 dihydrochlorideGGTI-286 is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277; inhibits processing of the geranylgeranylated protein Rap1A; inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM; reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells; has significant antiproliferative effect in human malignant glioma cells. |
| Name | GGTI-286 dihydrochloride |
|---|
| Description | GGTI-286 is a CAAX peptidomimetic that is a potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277; inhibits processing of the geranylgeranylated protein Rap1A; inhibits oncogenic K-Ras4B stimulation with IC50 of 1 uM; reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells; has significant antiproliferative effect in human malignant glioma cells. |
|---|---|
| References | References 1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26770-3. 2. Nishiya N, et al. Chem Biol. 2014 Apr 24;21(4):530-40. 3. Lerner EC, et al. Oncogene. 1997 Sep;15(11):1283-8. View Related Products by Target Other Targets |
| Molecular Formula | C23H32ClN3O3S |
|---|---|
| Molecular Weight | 466.037 |