GGTI-286

Modify Date: 2024-01-08 10:55:40

GGTI-286 structure	Common Name	GGTI-286
	CAS Number	171744-11-9	Molecular Weight	429.58
	Density	1.2±0.1 g/cm3	Boiling Point	626.9±55.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₁N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	332.9±31.5 °C

Use of GGTI-286

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].

Name	Methyl N-[(5-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-biphenylyl)carbonyl]-L-leucinate
Synonym	More Synonyms

Description	GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	IC50: 2 μM (Geranylgeranylation of Rap1A) in NIH3T3 cells[1]
References	[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.

Density	1.2±0.1 g/cm3
Boiling Point	626.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₁N₃O₃S
Molecular Weight	429.58
Flash Point	332.9±31.5 °C
Exact Mass	429.208618
LogP	3.76
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.588

Hazard Codes	Xi

L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester

Methyl N-[(5-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-biphenylyl)carbonyl]-L-leucinate

methyl N-[(5-{[(2R)-2-amino-3-sulfanylpropyl]amino}biphenyl-2-yl)carbonyl]-L-leucinate

GGTI-286

DC Chemicals Limited
China
Product Name: GGTI-286
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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