1044590-78-4
1044590-78-4 structure
- Name: GGTI 2418 sodium
- Chemical Name: GGTI 2418 sodium
- CAS Number: 1044590-78-4
- Molecular Formula: C23H30N5NaO4
- Molecular Weight: 463.514
- Create Date: 2020-01-12 10:09:44
- Modify Date: 2022-11-21 18:19:11
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GGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors.
| Name | GGTI 2418 sodium |
|---|
| Description | GGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors. |
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| References | References 1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558. 2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. View Related Products by Target Other Targets |
| Molecular Formula | C23H30N5NaO4 |
|---|---|
| Molecular Weight | 463.514 |