501010-05-5

501010-05-5 structure

Name: GGTI 2417
Chemical Name: Methyl N-({(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-1-piperazinyl}carbonyl)-L-leucinate
CAS Number: 501010-05-5
Molecular Formula: C₂₄H₃₃N₅O₄
Molecular Weight: 455.550
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-01-11 22:46:50
Modify Date: 2024-04-02 09:20:36
GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I; exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM; increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27.

Name	Methyl N-({(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-1-piperazinyl}carbonyl)-L-leucinate
Synonyms	L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester MFCD25976817 Methyl N-({(2S)-2-benzyl-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-1-piperazinyl}carbonyl)-L-leucinate

Description	GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I; exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM; increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27.
References	References 1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558. 2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. 3. Falsetti SC, et al. Mol Cell Biol. 2007 Nov;27(22):8003-14. View Related Products by Target Other Targets