3-deoxyvasicine

Modify Date: 2024-01-02 01:18:42

3-deoxyvasicine structure	Common Name	3-deoxyvasicine
	CAS Number	495-59-0	Molecular Weight	172.22600
	Density	1.23g/cm3	Boiling Point	311.6ºC at 760mmHg
	Molecular Formula	C₁₁H₁₂N₂	Melting Point	96.5-97.5 °C
	MSDS	N/A	Flash Point	142.3ºC

Use of 3-deoxyvasicine

Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].

Name	1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
Synonym	More Synonyms

Description	Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	BChE:2 μM (IC50) AChE:17 μM (IC50) MAO-A:2 μM (IC50)
In Vivo	Desoxypeganine (10-30 mg/kg，灌胃，每天一次，连续 16 天) 剂量依赖性地降低乙醇摄入量和乙醇偏好[1]。 Animal Model: Female Alko alcohol (AA) rats (Thirty eight adult)[1] Dosage: 10, 20, 30 mg/kg Administration: Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days Result: Abolished ethanol preference.
References	[1]. Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. [2]. Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51.

Density	1.23g/cm3
Boiling Point	311.6ºC at 760mmHg
Melting Point	96.5-97.5 °C
Molecular Formula	C₁₁H₁₂N₂
Molecular Weight	172.22600
Flash Point	142.3ºC
Exact Mass	172.10000
PSA	15.60000
LogP	1.69950

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