495-59-0

495-59-0 structure

Name: 3-deoxyvasicine
Chemical Name: 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
CAS Number: 495-59-0
Molecular Formula: C₁₁H₁₂N₂
Molecular Weight: 172.22600
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2016-08-28 13:38:08
Modify Date: 2024-01-02 01:18:42
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].

Name	1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
Synonyms	2,3-trimethylene-3,4-dihydroquinazoline deoxypeganine 3-deoxyvasicine Deoxypeganin Desoxypeganine deoxyvasicine 3-Deoxypeganine deoxypeganol

Description	Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	BChE:2 μM (IC50) AChE:17 μM (IC50) MAO-A:2 μM (IC50)
In Vivo	Desoxypeganine (10-30 mg/kg，灌胃，每天一次，连续 16 天) 剂量依赖性地降低乙醇摄入量和乙醇偏好[1]。 Animal Model: Female Alko alcohol (AA) rats (Thirty eight adult)[1] Dosage: 10, 20, 30 mg/kg Administration: Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days Result: Abolished ethanol preference.
References	[1]. Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. [2]. Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51.