(S)-Salsolidine

Modify Date: 2024-01-08 16:07:52

(S)-Salsolidine Structure
(S)-Salsolidine structure
Common Name (S)-Salsolidine
CAS Number 493-48-1 Molecular Weight 207.27
Density 1.034g/cm3 Boiling Point 313.4ºC at 760mmHg
Molecular Formula C12H17NO2 Melting Point N/A
MSDS N/A Flash Point 127.1ºC

 Use of (S)-Salsolidine


(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1].

 Names

Name salsolidine
Synonym More Synonyms

 (S)-Salsolidine Biological Activity

Description (S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Salsolidine is a dopamine-derived tetrahydroisoquinoline-alkaloid which possesses an asymmetric center at C-1 and exists as R and S enantiomers[1].
References

[1]. Dostert P, et al. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J Neural Transm. 1988;74(2):61-74.

 Chemical & Physical Properties

Density 1.034g/cm3
Boiling Point 313.4ºC at 760mmHg
Molecular Formula C12H17NO2
Molecular Weight 207.27
Flash Point 127.1ºC
Exact Mass 207.12600
PSA 30.49000
LogP 2.23930
Vapour Pressure 0.000496mmHg at 25°C
Index of Refraction 1.509

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX5018500
CHEMICAL NAME :
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-
CAS REGISTRY NUMBER :
493-48-1
LAST UPDATED :
199312
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H17-N-O2
MOLECULAR WEIGHT :
207.30
WISWESSER LINE NOTATION :
T66 CMT&J B1 HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,249,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 15(2),54,1981

 Synonyms

rac-salsolidine
6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
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