Bergenin

Modify Date: 2025-08-23 10:17:28

Bergenin structure	Common Name	Bergenin
	CAS Number	477-90-7	Molecular Weight	328.271
	Density	1.6±0.1 g/cm3	Boiling Point	658.9±55.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆O₉	Melting Point	237-240 °C(lit.)
	MSDS	Chinese USA	Flash Point	250.7±25.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Bergenin

Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].

Name	Bengenin
Synonym	More Synonyms

Description	Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenylpropanoids
References	[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50. [2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54. [3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Phenylpropanoids

References

[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50.

[2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.

[3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

Density	1.6±0.1 g/cm3
Boiling Point	658.9±55.0 °C at 760 mmHg
Melting Point	237-240 °C(lit.)
Molecular Formula	C₁₄H₁₆O₉
Molecular Weight	328.271
Flash Point	250.7±25.0 °C
Exact Mass	328.079437
PSA	145.91000
LogP	0.05
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.655
Storage condition	?20°C

Bergenin MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ0337200

Precursor 9
CAS#:1240795-78-1 8,10-di-O-benzy... CAS#:82958-44-9 11-O-Galloylbergenin CAS#:82958-45-0 4-O-Galloylbergenin CAS#:13265-84-4 D-Glucal
CAS#:842132-50-7 (1,5-anhydro-2-... CAS#:99-24-1 Methyl gallate CAS#:13089-97-9 methyl 3,5-diac... CAS#:24093-81-0 (4'-O-methyl)me...
CAS#:13326-69-7 methyl 3,5-dibe...
DownStream 3
CAS#:14531-47-6 Bergenin pentaa... CAS#:149-91-7 Gallic acid CAS#:33815-57-5 Di-O-methylbergenin

Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb.

Bioorg. Med. Chem. 16 , 1337-44, (2008)

Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolo...

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.

J. Chromatogr. Sci. 53 , 824-9, (2015)

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and menisdaurin in the methanol extracts of aerial...

A novel lactone from Tripterospermum chinense.

Yao Xue Xue Bao 47(11) , 1517-20, (2012)

A novel lactone, tripterospermumcins E (1), along with four known compounds, sweroside (2), loganic acid (3), 8-epi-kingiside (4) and bergenin (5), were isolated from the aerial parts of Tripterosperm...

Vakerin

Ai Cha Su

Bergenitol

Bergenit

Peltophorin

CORYLOPSIN

(+)-Bergenin

3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one

4-Methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-a-resorcylic Acid d-Lactone

Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-

3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c][2]benzopyran-6(2H)-one

BERGENIN

Bergenin:Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, [2R-(2,3,4,4a, 10b)]-,

CUSCUTIN

Ardisic Acid B

MFCD00133120

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Shanghai Nianxing Industrial Co., Ltd
China
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DC Chemicals Limited
China
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Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Bergenin
Price: ￥Inquiry/10g ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/50mg
Purity: 98.0%
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Contact: Xiyao Wang
Email: 3623107365@qq.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Bengenin 477-90-7
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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