Anti-inflammatory agent 15

Modify Date: 2024-01-24 09:53:03

Anti-inflammatory agent 15 Structure
Anti-inflammatory agent 15 structure
Common Name Anti-inflammatory agent 15
CAS Number 474516-87-5 Molecular Weight 284.42
Density N/A Boiling Point N/A
Molecular Formula C17H20N2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anti-inflammatory agent 15


Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research[1].

 Names

Name Anti-inflammatory agent 15

 Anti-inflammatory agent 15 Biological Activity

Description Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research[1].
Related Catalog
Target

TNF-α

In Vitro Anti-inflammatory agent 15 (compound 29) is active in the reduction of accumulated nitrite, with an IC50 of 71.7 ± 1.1 μM[1].
References

[1]. Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.

 Chemical & Physical Properties

Molecular Formula C17H20N2S
Molecular Weight 284.42