2408836-40-6

2408836-40-6 structure

Name: Anti-inflammatory agent 21
Chemical Name: Anti-inflammatory agent 21
CAS Number: 2408836-40-6
Molecular Formula: C₂₄H₂₁FO₆
Molecular Weight: 424.42
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2022-06-26 19:54:52
Modify Date: 2024-01-09 15:18:48
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].

Name	Anti-inflammatory agent 21

Description	Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
Target	IC50: 0.76 μM (NO)[1]
References	[1]. Chen LZ, Wu J, Li K, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020;206:112722.

Molecular Formula	C₂₄H₂₁FO₆
Molecular Weight	424.42