NPD-001

Modify Date: 2025-09-18 16:51:12

NPD-001 Structure
NPD-001 structure
 Common Name NPD-001
CAS Number 469863-16-9 Molecular Weight 584.71
Density N/A Boiling Point N/A
Molecular Formula C33H40N6O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NPD-001


NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].

 Names

Name NPD-001

 NPD-001 Biological Activity

Description NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].
Related Catalog
Target

IC50: 3 nM (TbrPDEB2), 4 nM (TbrPDEB1)[1]

References

[1]. Veerman J, et al. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.

 Chemical & Physical Properties

Molecular Formula C33H40N6O4
Molecular Weight 584.71
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Chemsrc provides NPD-001(CAS#:469863-16-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of NPD-001 are included as well.>> amp version: NPD-001

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