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NPD-001

Names

[ CAS No. ]:
469863-16-9

[ Name ]:
NPD-001

Biological Activity

[Description]:

NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Infection

[Target]

IC50: 3 nM (TbrPDEB2), 4 nM (TbrPDEB1)[1]


[References]

[1]. Veerman J, et al. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H40N6O4

[ Molecular Weight ]:
584.71

Related Compounds