469863-16-9

469863-16-9 structure

Name: NPD-001
Chemical Name: NPD-001
CAS Number: 469863-16-9
Molecular Formula: C₃₃H₄₀N₆O₄
Molecular Weight: 584.71
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-08-11 15:25:13
Modify Date: 2024-01-05 18:41:18
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].

Name	NPD-001

Description	NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Infection
Target	IC50: 3 nM (TbrPDEB2), 4 nM (TbrPDEB1)[1]
References	[1]. Veerman J, et al. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.

Molecular Formula	C₃₃H₄₀N₆O₄
Molecular Weight	584.71