Lu AE58054 (Hydrochloride)

Modify Date: 2024-01-31 07:24:33

Lu AE58054 (Hydrochloride) structure	Common Name	Lu AE58054 (Hydrochloride)
	CAS Number	467458-02-2	Molecular Weight	434.831
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀ClF₅N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lu AE58054 (Hydrochloride)

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.

Name	2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine,hydrochloride
Synonym	More Synonyms

Description	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Arnt J, et al. Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. [2]. Witten L, et al. Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.

Description

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

References

6-fluoroindole

CAS#:399-51-9

Lu AE58054 (Hyd...

CAS#:467458-02-2

Literature: H. LUNDBECK A/S Patent: US2011/152539 A1, 2011 ;

1-(6-Fluoro-1H-...

CAS#:343-93-1

Lu AE58054 (Hyd...

CAS#:467458-02-2

Literature: H. LUNDBECK A/S Patent: US2011/152539 A1, 2011 ;

Precursor 2
CAS#:399-51-9 6-fluoroindole CAS#:343-93-1 1-(6-Fluoro-1H-...
DownStream 0

1H-Indole-3-ethanamine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-, hydrochloride (1:1)

CS-1359

2-(6-Fluoro-1H-indol-3-yl)-N-[3-(2,2,3,3-tetrafluoropropoxy)benzyl]ethanamine hydrochloride (1:1)

N-(2-(6-fluoro-1H-indol-3-yl)ethyl)-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride

Lu AE58054 (Hydrochloride)

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Price: $290/10mM*1mLinDMSO