Linolenic acid

Modify Date: 2025-08-23 18:06:37

Linolenic acid Structure
Linolenic acid structure
 Common Name Linolenic acid
CAS Number 463-40-1 Molecular Weight 278.430
Density 0.9±0.1 g/cm3 Boiling Point 443.4±0.0 °C at 760 mmHg
Molecular Formula C18H30O2 Melting Point -11 °C(lit.)
MSDS Chinese USA Flash Point 275.7±14.4 °C

 Use of Linolenic acid


α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].

 Names

Name α-linolenic acid
Synonym More Synonyms

 Linolenic acid Biological Activity

Description α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
Related Catalog
Target

PI3K

Akt

In Vitro α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].
In Vivo α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1]. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1]. α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1]. Animal Model: Mice weighing at 18 ~ 22 g[1] Dosage: 50, 100, 250 mg/kg Administration: For 10 days Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg.
References

[1]. Yang Q, et al. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. BMC Complement Altern Med. 2014 Sep 23;14:348.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 443.4±0.0 °C at 760 mmHg
Melting Point -11 °C(lit.)
Molecular Formula C18H30O2
Molecular Weight 278.430
Flash Point 275.7±14.4 °C
Exact Mass 278.224579
PSA 37.30000
LogP 6.50
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.491
Storage condition 2-8°C
Water Solubility INSOLUBLE

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes F;Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
HS Code 2916190090

 Synthetic Route

Methyl Linolenate structure

Methyl Linolenate

CAS#:301-00-8

~95%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Literature: Sandri; Viala Synthesis, 1995 , # 3 p. 271 - 275
Triclosan structure

Triclosan

CAS#:3380-34-5

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Literature: DSM IP ASSETS B.V. Patent: US2012/277772 A1, 2012 ;
6-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-β-D-fructofuranosyl-(2->1)-α-D-glucopyranoside structure

6-O-[(9Z,12Z,15...

CAS#:1053246-35-7

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

sucrose structure

sucrose

CAS#:57-50-1

Literature: Cheng, Jin-Tang; Li, Yan; He, Juan; Li, Xing-Yao; Wu, Xing-De; Shao, Li-Dong; Dong, Liao-Bin; Deng, Xu; Gao, Xiu; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi Helvetica Chimica Acta, 2012 , vol. 95, # 7 p. 1158 - 1163
3-O-β-D-galactopyranosyl-1-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-sn-glycerol structure

3-O-β-D-galacto...

CAS#:171520-42-6

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Methyl Linolenate structure

Methyl Linolenate

CAS#:301-00-8

(2R)-Glycerol-O-β-D-galactopyranoside structure

(2R)-Glycerol-O...

CAS#:16232-91-0

Literature: Baruah, Putul; Baruah,Nabin C.; Sharma, Ram P.; Baruah, Jogendra N.; Kulanthaivel, Palianappan; Herz, Werner Phytochemistry (Elsevier), 1983 , vol. 22, # 8 p. 1741 - 1744
N/A structure

N/A

CAS#:87584-96-1

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Literature: Sashidhara, Koneni V.; Singh, Suriya P.; Misra, Sweta; Gupta, Jyoti; Misra-Bhattacharya, Shailja European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 230 - 235
Octadecanoic acid,9,10,12,13,15,16-hexabromo- structure

Octadecanoic ac...

CAS#:4167-08-2

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Literature: Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79
Ethanol structure

Ethanol

CAS#:64-17-5

Octadecanoic acid,9,10,12,13,15,16-hexabromo- structure

Octadecanoic ac...

CAS#:4167-08-2

~%

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Linolenic acid Structure

Linolenic acid

CAS#:463-40-1

Literature: Hazura Monatshefte fuer Chemie, 1887 , vol. 8, p. 267 Full Text Show Details Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79

 Customs

HS Code 2916190090
Summary 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

 Articles113

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 Synonyms

EINECS 207-334-8
(9Z,12Z,15Z)-linolenic acid
9,12,15-all-cis-Octadecatrienoic acid
9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)-
Linolein,2-mono
2-linoleoyl-sn-glycerol
2-Monolinolein
(9Z,12Z,15Z)-Octadeca-9,12,15-trienoic acid
2-Glyceryl 9,12-octadecadienoate
9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl)ethyl ester
linoleic acid monoacylglycerol
9,12,15-OCTADECATRIENOIC ACID, (Z,Z,Z)-
Glyceryl 2-linoleate
9Z,12Z,15Z-octadecatrienic acid
2-monolinoleoylglycerol
9Z,12Z,15Z-Octadecatrienoic acid
(9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid
MFCD00065720
a-Linolenic Acid
octadecatrienoic acid
9,12,15-octadecatrienoic acid
alpha-linolenic acid
(all-Z)-9,12,15-Octadecatrienoic acid
(9Z,12Z)-1,3-dihydroxypropan-2-yl octadeca-9,12-dienoate
Linolenic acid
C18:3 (9,12,15-cis all)
2-Linoleoylglycerol
9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- (9CI)
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