Linolenic acid

Names

[ CAS No. ]:
463-40-1

[ Name ]:
Linolenic acid

[Synonym ]:
EINECS 207-334-8
(9Z,12Z,15Z)-linolenic acid
9,12,15-all-cis-Octadecatrienoic acid
9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)-
Linolein,2-mono
2-linoleoyl-sn-glycerol
2-Monolinolein
(9Z,12Z,15Z)-Octadeca-9,12,15-trienoic acid
2-Glyceryl 9,12-octadecadienoate
9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl)ethyl ester
linoleic acid monoacylglycerol
9,12,15-OCTADECATRIENOIC ACID, (Z,Z,Z)-
Glyceryl 2-linoleate
9Z,12Z,15Z-octadecatrienic acid
2-monolinoleoylglycerol
9Z,12Z,15Z-Octadecatrienoic acid
(9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid
MFCD00065720
a-Linolenic Acid
octadecatrienoic acid
9,12,15-octadecatrienoic acid
alpha-linolenic acid
(all-Z)-9,12,15-Octadecatrienoic acid
(9Z,12Z)-1,3-dihydroxypropan-2-yl octadeca-9,12-dienoate
Linolenic acid
C18:3 (9,12,15-cis all)
2-Linoleoylglycerol
9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- (9CI)

Biological Activity

[Description]:

α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

PI3K

Akt

[In Vitro]

α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].

[In Vivo]

α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1]. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1]. α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1]. Animal Model: Mice weighing at 18 ~ 22 g[1] Dosage: 50, 100, 250 mg/kg Administration: For 10 days Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg.

[References]

[1]. Yang Q, et al. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. BMC Complement Altern Med. 2014 Sep 23;14:348.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
443.4±0.0 °C at 760 mmHg

[ Melting Point ]:
-11 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₀O₂

[ Molecular Weight ]:
278.430

[ Flash Point ]:
275.7±14.4 °C

[ Exact Mass ]:
278.224579

[ PSA ]:
37.30000

[ LogP ]:
6.50

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.491

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
F;Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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