Adenosine 5′-monophosphate disodium salt
Modify Date: 2024-01-02 12:25:52
Adenosine 5′-monophosphate disodium salt structure
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Common Name | Adenosine 5′-monophosphate disodium salt | ||
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| CAS Number | 4578-31-8 | Molecular Weight | 391.185 | |
| Density | N/A | Boiling Point | 798.5ºC at 760 mmHg | |
| Molecular Formula | C10H12N5Na2O7P | Melting Point | 232-235ºC | |
| MSDS | USA | Flash Point | 436.7ºC | |
Use of Adenosine 5′-monophosphate disodium saltAdenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3]. |
| Name | Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3]. |
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| Related Catalog | |
| Target |
A2BR |
| In Vivo | Adenosine 5'-monophosphate (10 和 13 mg/L，添加在蒸馏水中，25 周) disodium 改善 HFD 诱导的糖尿病小鼠的葡萄糖代谢[1]。 Adenosine 5'-monophosphate (40-800 mg/kg，i.p.) disodium 通过小鼠体内的腺苷受体降低体温[2]。 Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1] Dosage: 10 and 13 mg/L Administration: Added in distilled water, for 25 weeks Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle. |
| References |
| Boiling Point | 798.5ºC at 760 mmHg |
|---|---|
| Melting Point | 232-235ºC |
| Molecular Formula | C10H12N5Na2O7P |
| Molecular Weight | 391.185 |
| Flash Point | 436.7ºC |
| Exact Mass | 391.026978 |
| PSA | 201.54000 |
| Storage condition | −20°C |
| Water Solubility | H2O: soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7481600 |
CAS#:108321-99-9
CAS#:61-19-8
CAS#:3387-36-8|
Regulation of AMPK by the ubiquitin proteasome system.
Am. J. Pathol. 178 , 4-11, (2011) The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinat... |
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New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK.
Clin. Cancer Res. 16 , 3322-3328, (2010) Although the role of metabolic syndrome (MS) and a high fat diet in prostate cancer (PCa) risk is still a matter of intense debate, it is becoming increasingly clear that obesity can cause perturbatio... |
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Identification of a novel CaMKK substrate.
Biochem. Biophys. Res. Commun. 410 , 45-51, (2011) Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates specific downstream protein kinases including CaMKI, CaMKIV and 5'-AMP-activated protein kinase. In order to exam... |
| Disodium 5'-O-phosphonatoadenosine |
| Disodium adenosine 5'-phosphate |
| Adenosine 5'-monophosphate disodium salt |
| MFCD00065023 |
| Adenosine-5'-monophosphate disodium salt |
| Dinatrium-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-amin |
| Adenosine 5′-monophosphate sodium salt |
| AMP disodium salt |
| EINECS 224-961-2 |
| 5'-Adenylic acid, sodium salt (1:2) |
| 5'-AMP-Na2 |
| Adenosine 5’-Monophosphate Disodium Salt |
| 5′-AMP-Na2 |
| Disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Adenosine 5′-monophosphate disodium salt
- Price: ￥278.0/25g ￥98.0/5g ￥98.0/20mg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Disodium adenosine 5'-phosphate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
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- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Adenosine 5'-monophosphate disodium salt
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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