Adenosine 5′-monophosphate disodium salt

Modify Date: 2025-08-25 09:49:29

Adenosine 5′-monophosphate disodium salt structure	Common Name	Adenosine 5′-monophosphate disodium salt
	CAS Number	4578-31-8	Molecular Weight	391.185
	Density	N/A	Boiling Point	798.5ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₂N₅Na₂O₇P	Melting Point	232-235ºC
	MSDS	USA	Flash Point	436.7ºC

Use of Adenosine 5′-monophosphate disodium salt

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].

Name	Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Synonym	More Synonyms

Description	Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2BR
In Vivo	Adenosine 5'-monophosphate (10 和 13 mg/L，添加在蒸馏水中，25 周) disodium 改善 HFD 诱导的糖尿病小鼠的葡萄糖代谢[1]。 Adenosine 5'-monophosphate (40-800 mg/kg，i.p.) disodium 通过小鼠体内的腺苷受体降低体温[2]。 Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1] Dosage: 10 and 13 mg/L Administration: Added in distilled water, for 25 weeks Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
References	[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473. [3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206.

Boiling Point	798.5ºC at 760 mmHg
Melting Point	232-235ºC
Molecular Formula	C₁₀H₁₂N₅Na₂O₇P
Molecular Weight	391.185
Flash Point	436.7ºC
Exact Mass	391.026978
PSA	201.54000
Storage condition	−20°C
Water Solubility	H2O: soluble

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7481600

CHEMICAL NAME :: 5'-Adenylic acid, disodium salt

CAS REGISTRY NUMBER :: 4578-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N5-O7-P.2Na

MOLECULAR WEIGHT :: 391.22

WISWESSER LINE NOTATION :: T56 BM DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 33,24,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7481600

Adenosine

CAS#:58-61-7

Adenosine 5′-mo...

CAS#:4578-31-8

Literature: Barai, Vladimir N.; Zinchenko, Anatoli I.; Kvach, Sergei V.; Titovich, Olga I.; Rubinova, Elena B.; Kalinichenko, Elena N.; Mikhailopulo, Igor A. Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2827 - 2832

Precursor 1
CAS#:58-61-7 Adenosine
DownStream 3
CAS#:108321-99-9 D-RIBULOSE 5-PH... CAS#:61-19-8 5'-Adenylic acid CAS#:3387-36-8 5'-UMP disodium salt

Regulation of AMPK by the ubiquitin proteasome system.

Am. J. Pathol. 178 , 4-11, (2011)

The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinat...

New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK.

Clin. Cancer Res. 16 , 3322-3328, (2010)

Although the role of metabolic syndrome (MS) and a high fat diet in prostate cancer (PCa) risk is still a matter of intense debate, it is becoming increasingly clear that obesity can cause perturbatio...

Identification of a novel CaMKK substrate.

Biochem. Biophys. Res. Commun. 410 , 45-51, (2011)

Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates specific downstream protein kinases including CaMKI, CaMKIV and 5'-AMP-activated protein kinase. In order to exam...

Disodium 5'-O-phosphonatoadenosine

Disodium adenosine 5'-phosphate

Adenosine 5'-monophosphate disodium salt

MFCD00065023

Adenosine-5'-monophosphate disodium salt

Dinatrium-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-amin

Adenosine 5′-monophosphate sodium salt

AMP disodium salt

EINECS 224-961-2

5'-Adenylic acid, sodium salt (1:2)

5'-AMP-Na2

Adenosine 5’-Monophosphate Disodium Salt

5′-AMP-Na2

Disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate

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China
Product Name: Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
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Adenosine 5′-monophosphate disodium salt

Use of Adenosine 5′-monophosphate disodium salt

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MSDS

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