NU 6140
Modify Date: 2024-02-16 17:43:15
NU 6140 structure
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Common Name | NU 6140 | ||
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| CAS Number | 444723-13-1 | Molecular Weight | 422.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30N6O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of NU 6140NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs[1]. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively[2]. Anti-cancer activity[1][2]. |
| Name | 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs[1]. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively[2]. Anti-cancer activity[1][2]. |
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| Related Catalog | |
| Target |
cdk2-cyclin A:0.41 μM (IC50) CDK1-Cyclin B:6.6 μM (IC50) CDK4-Cyclin D:5.5 μM (IC50) cdk5-p25:15 μM (IC50) cdk7-cyclin H:3.9 μM (IC50) Aurora A:67 nM (IC50) Aurora B:35 nM (IC50) |
| In Vitro | NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC50s of 0.41, 6.6, 5.5, 15 and 3.9 μM, respectively[1]. NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population[1]. |
| References |
| Molecular Formula | C23H30N6O2 |
|---|---|
| Molecular Weight | 422.52 |
| Exact Mass | 422.24300 |
| PSA | 96.03000 |
| LogP | 4.61060 |
| RIDADR | NONH for all modes of transport |
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| Cdk2 Inhibitor IV,NU6140 |
| HMS3229E18 |
| IN1369 |