444723-13-1

444723-13-1 structure

Name: NU 6140
Chemical Name: 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
CAS Number: 444723-13-1
Molecular Formula: C₂₃H₃₀N₆O₂
Molecular Weight: 422.52
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2016-11-21 22:32:46
Modify Date: 2024-02-16 17:43:15
NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs[1]. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively[2]. Anti-cancer activity[1][2].

Name	4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
Synonyms	Cdk2 Inhibitor IV,NU6140 HMS3229E18 IN1369

Description	NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs[1]. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively[2]. Anti-cancer activity[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	cdk2-cyclin A:0.41 μM (IC50) CDK1-Cyclin B:6.6 μM (IC50) CDK4-Cyclin D:5.5 μM (IC50) cdk5-p25:15 μM (IC50) cdk7-cyclin H:3.9 μM (IC50) Aurora A:67 nM (IC50) Aurora B:35 nM (IC50)
In Vitro	NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC50s of 0.41, 6.6, 5.5, 15 and 3.9 μM, respectively[1]. NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population[1].
References	[1]. Pennati M, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.

RIDADR	NONH for all modes of transport