JKC 363 TFA

Modify Date: 2025-08-27 20:09:11

JKC 363 TFA structure	Common Name	JKC 363 TFA
	CAS Number	436083-30-6	Molecular Weight	1506.708
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₉H₉₁N₁₉O₁₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JKC 363 TFA

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

Name	jkc 363
Synonym	More Synonyms

Description	JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
References	[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. [2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

References

[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282.

[2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.

Density	1.6±0.1 g/cm3
Molecular Formula	C₆₉H₉₁N₁₉O₁₆S₂
Molecular Weight	1506.708
Exact Mass	1505.633301
PSA	603.20000
LogP	-3.67
Index of Refraction	1.731
Storage condition	-20°C

1-{[(4R,10S,13S,16R,19S,22S)-13-(3-Carbamimidamidopropyl)-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,1 ;4,17,20,23-heptaazacyclohexacosan-4-yl]carbonyl}-L-prolyl-L-prolyl-L-lysyl-L-α-asparagine

L-α-Asparagine, 1-[[(4R,10S,13S,16R,19S,22S)-13-[3-[(aminoiminomethyl)amino]propyl]-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenylmethyl)-6,9,12,15,18, 21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacos-4-yl]carbonyl]-L-prolyl-L-prolyl-L-lysyl-

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JKC 363 TFA

Use of JKC 363 TFA

Names

JKC 363 TFA Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.