74513-77-2
74513-77-2 structure
- Name: Ro 363
- Chemical Name: 4-[3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropoxy]benzene-1,2-diol
- CAS Number: 74513-77-2
- Molecular Formula: C19H25NO6
- Molecular Weight: 363.40500
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2017-12-09 18:03:23
- Modify Date: 2024-01-10 18:24:49
-
Ro 363 is a potent and highly selective β1-adrenoceptor agonist. RO 363 is an effective inotropic stimulant, and is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].
| Name | 4-[3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropoxy]benzene-1,2-diol |
|---|---|
| Synonyms |
1,2-Benzenediol,4-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-hydroxypropoxy)-,(+-)
Ro 363 C19H25NO6 1-(3,4-Dimethoxyphenethylamino)-3-(3,4-dihydroxyphenoxy)-2-propanol |
| Description | Ro 363 is a potent and highly selective β1-adrenoceptor agonist. RO 363 is an effective inotropic stimulant, and is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
β1-adrenoceptor[1] |
| In Vitro | Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses[1]. RO 363 is approximately half as potent as (-)-Isoprenaline in tissues where actions are due to β1-receptor activation (guinea-pig atrial and ileal preparations and ventricular strips from the rabbit, rat and guinea-pig[2]. In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations[2]. |
| In Vivo | In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1]. Ro 363 elicits ventricular arrhythmias following the administration of subarrhythmic doses of ouabain and increases the number of subauricular escape beats which occurred during vagal nerve stimulation in non-ouabain treated animals[1]. |
| References |
| Density | 1.245g/cm3 |
|---|---|
| Boiling Point | 600.3ºC at 760 mmHg |
| Molecular Formula | C19H25NO6 |
| Molecular Weight | 363.40500 |
| Flash Point | 316.8ºC |
| Exact Mass | 363.16800 |
| PSA | 100.41000 |
| LogP | 2.07790 |
| Index of Refraction | 1.587 |