JKC-301

Modify Date: 2024-01-09 09:05:47

JKC-301 structure	Common Name	JKC-301
	CAS Number	136553-96-3	Molecular Weight	624.72800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₄N₆O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JKC-301

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].

Name	2-[(3R,6R,9S,12R,15S)-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
Synonym	More Synonyms

Description	JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
Target	Endothelin A receptor[1][2].
References	[1]. Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. [2]. Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76.

Molecular Formula	C₃₂H₄₄N₆O₇
Molecular Weight	624.72800
Exact Mass	624.32700
PSA	189.80000
LogP	2.47420
InChIKey	KHRTUHCOJNQEQG-CSXHVWADSA-N
SMILES	CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CC(C)C)NC1=O

JKC-301 MSDS(Chinese)

Cyclo(D-Asp-Pro-D-Ile-Leu-D-Trp)

JKC 301

JKC-301

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Taiwan Oyi peptide Co. Ltd
China
Product Name: CYCLO(-D-ASP-PRO-D-ILE-LEU-D-TRP)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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