Ro 363 hydrochloride
Modify Date: 2025-09-16 17:39:09
Ro 363 hydrochloride structure
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Common Name | Ro 363 hydrochloride | ||
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| CAS Number | 250580-70-2 | Molecular Weight | 399.87 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H26ClNO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ro 363 hydrochlorideRo 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3]. |
| Name | Ro 363 hydrochloride |
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| Description | Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3]. |
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| Related Catalog | |
| In Vitro | Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses[1]. In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations[2]. |
| In Vivo | In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1]. |
| References |
| Molecular Formula | C19H26ClNO6 |
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| Molecular Weight | 399.87 |