BAY-0069
Modify Date: 2024-04-03 20:06:44
BAY-0069 structure
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Common Name | BAY-0069 | ||
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| CAS Number | 420826-65-9 | Molecular Weight | 466.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H16BrN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAY-0069BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1]. |
| Name | BAY-0069 |
|---|
| Description | BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1]. |
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| Related Catalog | |
| Target |
hPPARγ:6.3 nM (IC50) mouse PPARγ:24 nM (IC50) |
| In Vitro | BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM[1]. BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9[1]. Cell Proliferation Assay[1] Cell Line: PPARγ-amplified cell line UM-UC-9 Concentration: 0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time: 7 days Result: Inhibited PPARγ-amplified cell line UM-UC-9 with an IC50 of 2.54 nM. |
| In Vivo | BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes[1]. Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice[1]. Route P.O. (100 mg/kg) I.P. S.C. AUC0-tlast (mg/L·h) 0.074 0.26 0.045 Cmax (nM) 35 59 4.4 |
| Molecular Formula | C22H16BrN3O4 |
|---|---|
| Molecular Weight | 466.28 |