420826-65-9

420826-65-9 structure
420826-65-9 structure
  • Name: BAY-0069
  • Chemical Name: BAY-0069
  • CAS Number: 420826-65-9
  • Molecular Formula: C22H16BrN3O4
  • Molecular Weight: 466.28
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
  • Create Date: 2022-12-12 07:28:03
  • Modify Date: 2025-09-10 14:16:37
  • BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1].

Name BAY-0069
Description BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1].
Related Catalog
Target

hPPARγ:6.3 nM (IC50)

mouse PPARγ:24 nM (IC50)

In Vitro BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM[1]. BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9[1]. Cell Proliferation Assay[1] Cell Line: PPARγ-amplified cell line UM-UC-9 Concentration: 0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time: 7 days Result: Inhibited PPARγ-amplified cell line UM-UC-9 with an IC50 of 2.54 nM.
In Vivo BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes[1]. Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice[1]. Route P.O. (100 mg/kg) I.P. S.C. AUC0-tlast (mg/L·h) 0.074 0.26 0.045 Cmax (nM) 35 59 4.4
Molecular Formula C22H16BrN3O4
Molecular Weight 466.28
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