420826-65-9
420826-65-9 structure
- Name: BAY-0069
- Chemical Name: BAY-0069
- CAS Number: 420826-65-9
- Molecular Formula: C22H16BrN3O4
- Molecular Weight: 466.28
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
- Create Date: 2022-12-12 07:28:03
- Modify Date: 2024-04-03 20:06:44
-
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1].
| Name | BAY-0069 |
|---|
| Description | BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
hPPARγ:6.3 nM (IC50) mouse PPARγ:24 nM (IC50) |
| In Vitro | BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM[1]. BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9[1]. Cell Proliferation Assay[1] Cell Line: PPARγ-amplified cell line UM-UC-9 Concentration: 0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time: 7 days Result: Inhibited PPARγ-amplified cell line UM-UC-9 with an IC50 of 2.54 nM. |
| In Vivo | BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes[1]. Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice[1]. Route P.O. (100 mg/kg) I.P. S.C. AUC0-tlast (mg/L·h) 0.074 0.26 0.045 Cmax (nM) 35 59 4.4 |
| Molecular Formula | C22H16BrN3O4 |
|---|---|
| Molecular Weight | 466.28 |