BAY 707
Modify Date: 2025-10-06 22:08:26
BAY 707 structure
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Common Name | BAY 707 | ||
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| CAS Number | 2109805-96-9 | Molecular Weight | 288.345 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H20N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAY 707BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM; demonstrates high selectivity in an in-house kinase panel, and shows an overall favorable physicochemical profile and in vitro pharmacokinetic properties with high metabolic stability; demonstrates a superior cellular target engagement with an EC50 of 7.6 nM compared with TH588, increases the cellular thermal stabilization of MTH1 with no effect on the expression of MTH2, OGG1, and MUTYH; shows a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies in vivo. |
| Name | N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide |
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| Synonym | More Synonyms |
| Description | BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM; demonstrates high selectivity in an in-house kinase panel, and shows an overall favorable physicochemical profile and in vitro pharmacokinetic properties with high metabolic stability; demonstrates a superior cellular target engagement with an EC50 of 7.6 nM compared with TH588, increases the cellular thermal stabilization of MTH1 with no effect on the expression of MTH2, OGG1, and MUTYH; shows a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies in vivo. |
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| References | References 1. Ellermann M, et al. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. View Related Products by Target DNA Repair Protein |
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C15H20N4O2 |
| Molecular Weight | 288.345 |
| Exact Mass | 288.158630 |
| LogP | 1.65 |
| Index of Refraction | 1.608 |
| N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide |
| 1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]- |